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Listar por autor "Mena Barragán, Teresa"
Mostrando ítems 1-8 de 8
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Artículo
A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis
Takai, Tomoko; Higaki, Katsumi; Aguilar Moncayo, Matilde; Mena Barragán, Teresa; Hirano, Yuki; Yura, Kei; García Moreno, M. Isabel; Ortiz Mellet, Carmen; García Fernández, José Manuel; Suzuki, Yoshiyuki (Cell Press, 2013)Lysosomal β-galactosidase (β-Gal) deficiency causes a group of disorders that include neuronopathic GM1 gangliosidosis and ...
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Artículo
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieteres, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Molecular Diversity Preservation International, 2018)A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
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Artículo
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieters, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (MDPI, 2021)A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
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Tesis Doctoral
Síntesis de iminoazúcares sp2 y evaluación de su actividad como chaperonas farmacológicas para el tratamiento de las enfermedades de Gaucher, Fabry y gangliosidosis GM1
Mena Barragán, Teresa (2013-12-13)Las enfermedades de depósito lisosomal (Lysosomal Storage Disorders, LSDs), entre las que se encuentran la enfermedad de ...
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Artículo
Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
Fuente, Alex de la; Mena Barragán, Teresa; Farrar-Tobar, Ronald A.; Verdaguer, Xavier; García Fernández, José Manuel; Ortiz Mellet, Carmen; Riera, Antoni (Royal Society of Chemistry, 2015)2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic ...
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Artículo
Structural basis of pharmacological chaperoning for human β-galactosidase
Suzuki, Hironori; Ohto, Umeharu; Higaki, Katsumi; Mena Barragán, Teresa; Aguilar Moncayo, Matilde; Ortiz Mellet, Carmen; Nanba, Eiji; García Fernández, José Manuel; Suzuki, Yoshiyuki; Shimizu, Toshiyuki (Elsevier, 2014)GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal β-galactosidase ...
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Artículo
Unexpected loss of stereoselectivity in glycosylation reactions during the synthesis of chondroitin sulfate oligosaccharides
Mena Barragán, Teresa; Paz, José L. de; Nieto, Pedro M. (Beilstein-Institut, 2019)Here, we present an exploratory study on the fluorous-assisted synthesis of chondroitin sulfate (CS) oligosaccharides. ...
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Artículo
Unprecedented Inhibition of Glycosidase-Catalyzed Substrate Hydrolysis by Nanodiamond-Grafted O-Glycosides
Siriwardena, A.; Khanal, M.; Barras, Alexandre; Bande, O.; Mena Barragán, Teresa; Ortiz Mellet, Carmen; García Fernández, José Manuel; Boukheroub, R.; Szunerits, S. (Royal Society of Chemistry, 2015)We report herein the unprecedented finding that α-O-glucosides and also α-O-mannosides, when conjugated on nanodiamond ...